GADD45B and hepatocellular carcinoma: Based on the known effect of the exogenous SAM on induction of the GADD45β expression [21] that inhibits proliferation of HCC cells during acute ischemia-hypoxia [22], we tested the expression of the Gadd45β transcript: however, it was similar in the livers of both SAM-treated and sham-treated mice (not shown).