ABCB4 and hepatocellular carcinoma: Encouraged by our previous finding of the reduced expression levels of enzymes regulating SAM metabolism in the liver of the Mdr2-KO mouse model of inflammation-mediated HCC [12], similarly to human HCC, in the current study, we tested the chemopreventive potential of SAM supplementation during the late precancerous stage of HCC development in this mouse model.