The AUC for ITGBL1, TGM4, KRT15 and HOXA7 was 0.843, 0.714, 0.787 and 0.646 (Figure 4A–4D); for all four DEGs combined, the AUC was 0.937 (Figure 4E), documenting that the altered levels of the four DEGs can differentiate patients with PCa from BPH controls. Here, KRT15 is linked to posterior cortical atrophy.