The results presented here provide further evidence for the importance of the endosomal recycling pathway in epithelial cell carcinogenesis, by driving the transport of adhesion proteins and receptor tyrosine kinases to the leading edge of migrating tumour cells and helps to explain how aberrant expression of regulators of this pathway can lead to the increased aggressiveness of a wide range of cancers. The gene discussed is NTRK1; the disease is neoplasm.