Inclusion of baseline BMI or T2D status as covariates did not significantly change the association between weight trajectories and CSF total tau/AΔ42 ratio (p = 0.005 and p = 0.005, respectively) or between weight trajectories and AV45 PET SUVR (p = 0.020 and p = 0.019, respectively). The gene discussed is MAPT; the disease is type 2 diabetes mellitus.