Arsenite can bind covalently with sulfhydryl groups in insulin molecules and receptors, enzymes such as pyruvate dehydrogenase and alpha keto-glutarate dehydrogenase, and glucose transporters (GLU-T), which may result in insulin resistance (Tseng, 2004[87]; Fröjdö et al., 2009[25]). The gene discussed is INS; the disease is Insulin resistance.