The major cause of type 1 diabetes mellitus (T1DM) is auto-immune reaction to the proteins produced by pancreatic islet cells, while type 2 diabetes mellitus (T2DM) may be a result of resistance to insulin, impaired secretion, as well as lifestyle changes (Holt, 2004[31]; Chan et al., 2009[14]). This evidence concerns the gene INS and type 2 diabetes mellitus.