IDDM also known as T1DM is usually diagnosed in childhood, not associated with weight gain but cannot be controlled without insulin administration; while T2DM occur in adults and mostly accompany weight gain, but treatment does not depend solely on insulin (Tabatabaei-Malazy et al., 2016[85]; Alberti and Zimmet,1998[3]). This evidence concerns the gene INS and type 1 diabetes mellitus.