ACHE and amyloidosis: It is well known that increased AChE activity within and around amyloid plaques increases cytotoxicity by promoting the aggregation of amyloid beta-peptides into fibrils which is more toxic than Aβ fibrils (Chacón et al., 2003[11]; Inestrosa et al., 2008[23]; Reyes et al., 2004[48]).