In addition to an association between higher levels of MKP1 expression in biopsies with overall higher survival rates of patients with glioblastomas, we showed that genetic overexpression of MKP1 in glioma cells and directly in the GSC population decreases proliferative ability, causes depletion of self-renewal, and subsequently decreases tumor initiation and progression. The gene discussed is DUSP1; the disease is glioma.