Electro-acupuncture at DU20 could markedly ameliorate cognitive impairments, reduce aberrant overexpression of β-amyloid1–42, and inhibit neuronal apoptosis, significantly enhance expression levels of mature brain-derived neurotrophic factor (BDNF) and pro-BDNF in APP/PS1 mice [24]. Here, BDNF is linked to Cognitive impairment.