Furthermore, the occurrence of in-hospital hyperglycaemia that required insulin treatment, which is an important adverse effect of corticosteroid therapy, was significantly higher at higher corticosteroid dosages (5.7, 11.2 and 23.5% for the no-corticosteroid, low-dose corticosteroid and high-dose corticosteroid groups, respectively). The gene discussed is INS; the disease is Hyperglycemia.