Univariate analysis revealed that the factors including platelet count (p = 0.037), prealbumin (p = 0.032), gamma-glutamyl transpeptidase (p = 0.027), prothrombin time (p = 0.005) and INR (p = 0.005), LSM (p < 0.001), the use of intraoperative blood transfusions (p = 0.005), the presence of cirrhosis (p < 0.001) and esophageal varices (p = 0.003) were significant predictors for PHLF. The gene discussed is F2; the disease is esophageal varices.