Using SOCS1−/− transgenic (Tg) mice, in which exogenous SOCS1 expression was restored only in T and B cells on a SOCS1−/− background, Hanada et al. found that constitutive IFN-γ-dependent STAT1 signaling is necessary for spontaneous development of colon cancer, which can be prevented with anti-IFN-γ antibody treatment [63]. The gene discussed is SOCS1; the disease is malignant colon neoplasm.