ICAM1 and melanoma: Another study reported that IFN-γ treatment of human melanoma cells in vitro resulted in favorable growth inhibition, but also increased expression of several markers expressed in advanced melanomas (e.g., HLA-DR and -DQ, ICAM-1 and A.1.43), suggesting the potential of IFN-γ to promote the development of more aggressive phenotypes in cancer cells [58].