As tumor cells express antigens that differ from their non-transformed counterparts, e.g., neo-antigens resulting from gene mutations, overexpressed cellular antigens or viral antigens [24], IFN-γ stimulates expression of tumor antigen-presenting MHC molecules to increase immunogenicity of tumor cells and makes them more susceptible to immune recognition and destruction [25,26,27]. Here, HLA-C is linked to neoplasm.