The results obtained from experiments like cell functional assays and qRT-PCR provide the insight that miR-204 might play a tumor suppressor role in gastric cancer by regulating five of its targets, CD55, CKS1B, CXCL1, GPRC5A and TNS4. Finally, luciferase reporter assays indicate that miR-204 might target CKS1B, CXCL1 and GPRC5A via their 3′UTR. The gene discussed is CD55; the disease is gastric cancer.