CSF3 and Decreased total neutrophil count: Although G-CSF administration will not be effective in reducing the risk of infection if the cause of neutropenia is independent of the G-CSF pathway, or if the mechanism by which the drug increases the risk of infections is not related to neutropenia (such as in the case of dexamethasone), appropriate use of G-CSF prophylaxis can be particularly important to reduce the risk related to a low neutrophil count.