INS and polycystic ovary syndrome: While a RCT on obese PCOS subjects (mean BMI of 34.9 kg/m2) found no effect for 1.5 g/d metformin administration for 3 months, larger studies and reviews revealed significant effects for 1.5 to 1.7 g/d metformin administration in reducing area under curve (AUC) for serum insulin after oral glucose administration, BMI and insulin in 1-6 months (18, 19).