A RCT indicated that metformin (1.7 g/d) administration for 6 month reduced WHR, weight, insulin, FBS and HOMA-IR more predominantly in obese (mean BMI = 37.2 kg/m2 and n = 40) compared with non-obese (mean BMI = 25.3 kg/m2 and n = 16) PCOS subjects (39). Here, INS is linked to polycystic ovary syndrome.