In this single center study, we sought to validate the findings of the IWG-MRT based on WHO 2016 PV diagnostic criteria, as well as identify additional risk factors for arterial versus venous thrombosis, including possible associations with the most frequent “non-driver” mutations: Tet methylcytosine dioxygenase 2 (TET2) (22%) and Additional sex combs like-1 (ASXL1) (12%)6. This evidence concerns the gene TET2 and acquired polycythemia vera.