FOXO3 and Alzheimer disease: In a GWAS of human longevity (living ≥90 years vs dying sooner), another SNP in FOXO3, which is in high LD with rs2153960 (r2 ∼0.9), ranked highly.34 Taking these findings together, the A allele of rs2153960 is linked with both higher risk of AD and a lower chance of reaching the age of 90 years.