Several primary immune deficiencies caused by mutations in SH2D1A, CTPS1, MAGT1, ITK, CD27, and CD70 are characterized by a high susceptibility to develop recurrent EBV‐driven B‐cell lymphoproliferative disorders (LPD), although these patients can also develop other infections (Veillette et al, 2013; Cohen, 2015; Tangye et al, 2017). The gene discussed is CTPS1; the disease is infection.