Finally, recent evidence suggests that p62 regulates the levels and/or functions of other ALS-FTD disease proteins (e.g., SOD1 and TDP-43) [85, 86], which is consistent with a prominent role of the misregulation of p62 in the disruption of protein homeostasis in ALS-FTD. The gene discussed is SOD1; the disease is frontotemporal dementia.