As noted above, the key biochemical property of Fhit is its ability to hydrolyze nucleoside 5′,5′-triphosphates, and while catalytically-inactive forms of Fhit are unable to function as tumor suppressors, a mutant (H96N) that binds to but does not hydrolyze nucleoside 5′,5′-triphosphates is nearly as effective as wild-type Fhit in suppressing tumor formation [12]. This evidence concerns the gene FHIT and neoplasm.