However, the expression level of EMMPRIN was up-regulated in LAC (16/23, 69.6%) (p = 0.034), poorly differentiated lung cancer tissues (15/17, 88.2%) (p < 0.001), NSCLC cases with N2-N3 of lymph node metastasis (23/29, 79.3%) (p < 0.001) and NSCLC tissues of stages IIIB (18/20, 90%) (p < 0.001), as compared with LSCC (13/32, 40.6%), well-differentiated tissues (5/25, 20%), lung cancer cases with N0-N1 of lymph node metastasis (6/26, 23.1%) and those of stages IIA-IIIA (11/35, 31.4%). This evidence concerns the gene BSG and metastatic malignant neoplasm in the lymph nodes.