In parallel and to re-evaluate SSTR and CXCR4 expression in hepatoma cell lines, samples of three commonly used human hepatoblastoma (HepG2) and HCC cell lines (Hep3B, and HuH-7) as well as of the small cell lung cancer cell line NCI-H69 and the pancreatic neuroendocrine tumor cell line BON-1 (as positive controls) were embedded in paraffin blocks and stained for the different SSTRs and CXCR4. This evidence concerns the gene CXCR4 and hepatocellular carcinoma.