FASN and breast carcinoma: In MCF-7 human breast cancer cells, SREBP-1c mRNA levels and FASN mRNA levels are high, but SREBP-1a and SREBP-2 mRNA levels are low, and, after addition of epidermal growth factor (EGF), FASN and SREBP-1c mRNA levels are increased, while SREBP-1a and SREBP-2 mRNA levels are not [9].