SREBF1 and colorectal cancer: In CaCo-2 human colorectal cancer cells, 250 μM 18:2n-6, AA, 20:5n-3, or DHA, but not OA or stearic acid (18:0), reduces m-SREBP-1 protein expression and SREBP-1c, SREBP-1a, and FASN mRNA levels, but has no effect on SREBP-2 mRNA and protein levels [20].