The average tumor volumes in the above groups on the 16th day of the treatment period were as follows: control group, V = 2029.95 ± 425.59 mm3; endostatin group, V = 1781.75 ± 412.53 mm3; radiotherapy group, V = 1246.60 ± 606.83 mm3; and radiotherapy with endostatin treatment group, V = 453.35 ± 181.43 mm3. The gene discussed is COL18A1; the disease is neoplasm.