BIRC5 and central nervous system cancer: In this study we demonstrate, that the phenotype of glioma cells with ectopic overexpression of Survivin (i.e. G1 cell cycle arrest in p53 wild type cells, DNA damage, DNA damage response, and NHEJ) resembles to some extent the Survivin knockdown phenotype described in our previous work [40] and is mechanistically linked to the CPP function of Survivin.