BIRC5 and central nervous system cancer: In recent comprehensive studies we have elaborated that knockdown of Survivin in permanent as well as primary glioma cell lines had no impact on caspase-dependent apoptosis but instead lead to immense cellular polyploidy with cells having DNA contents up to 32n, poly-merotelic kinetochore-microtubuli connections, DNA damage, DNA damage response, and NHEJ [39, 40].