BDNF and obesity due to melanocortin 4 receptor deficiency: However, no study is available evaluating the role of this vitamin in obesity-induced brain inflammation; therefore, the primary hypothesis of the current experimental study was to investigate the influence of vitamin D on brain derived neurotropic factor (BDNF) and neuro-inflammatory factors including IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) with especial regard to hypothalamus and hippocampus in high-fat diet induced obese rats.