Despite a very small sample size, IGSP successfully identified in this cohort several known key risk genes–NKX2-5 (NK2 homeobox 5), GATA4 (GATA binding protein 4), and EYA1 (EYA transcriptional coactivator and phosphatase 1)–for CHD in humans or for heart development in animal models [31, 32]. The gene discussed is NKX2-5; the disease is coronary artery disorder.