In conclusion, this study demonstrated that flaccidoxide-13-acetate inhibits the migration and invasion of T24 and RT4 bladder cancer cells through the down-regulation of MMP-2 and MMP-9 expressions, and the process is controlled by the FAK/PI3K/AKT/mTOR pathway (Figure 7). This evidence concerns the gene AKT1 and urinary bladder carcinoma.