MMP2 and hepatocellular carcinoma: Similarly, the results of a recent study by Wu et al. [33] showed that the active compound sinulariolide, isolated from cultured soft coral Sinularia flexibilis, inhibited the migration and invasion of hepatocellular carcinoma cells, also through the FAK/PI3K/AKT/mTOR pathway, by inhibiting the expressions of MMP-2 and MMP-9.