INS and obesity due to melanocortin 4 receptor deficiency: To sum up, the miRNome of SAT after loss of weight, despite positive changes compared to the SAT of the obese, still differed from that of normal-weight subjects, suggesting that even after the normalization of body mass index (BMI), a period of obesity leaves a long-lasting imprint on the metabolism of adipose tissue regarding control of functions such as adipogenesis, lipid metabolism, the immune response, insulin signaling, atherosclerosis, ageing, cardiovascular diseases, neurodegenerative disorders and oncogenesis [13,28,29,30,31,32].