INS and neurodegenerative disease: Among other miRNAs with a lower expression in SAT-PO were those crucial for lipid metabolism, such as hsa-miR-144-3p involved in the decrease of HDL formation [28], for insulin signaling such as hsa-miR-96-5p that represses expression of the gene encoding insulin receptor INSR [29], for ageing such as hsa-miR-141-3p that accelerates the ageing of human mesenchymal cells [30], and for those promoting the development of cardiovascular and neurodegenerative diseases, such as hsa-miR-3615 and hsa-miR-15b-5p [31,32].