Although the most frequent condition treated with GH still remains GHD, other growth-related indications for GH treatment are TS, short stature homeobox-containing (SHOX) gene deficiency, Noonan syndrome, Prader-Willi syndrome, growth failure associated with chronic renal insufficiency, short stature in children born small for gestational age (SGA) who do not demonstrate catch-up growth and idiopathic short stature (ISS) (Table 1). Here, GH1 is linked to Prader-Willi syndrome.