HRs with Nephrolithiasis and Osteoporosis type 2 (Nephrolithiasis/osteoporosis, hypophosphatemic, 2, NPHLOP2, MIM 612287) is an autosomal dominant disease caused by mutations in the SLC9A3R1 (MIM 604990). The gene discussed is NHERF1; the disease is osteoporosis.