A positive staining for the latter three was shown in the α‐SMA+ stroma of colon cancer patient samples.140 The comparison of CM from patient‐derived oral SCC CAFs with that of fibroblasts isolated from healthy oral mucosa showed that CAFs secrete more proteins related to collagen metabolism, ECM organization, and disassembly. Here, ACTA1 is linked to malignant colon neoplasm.