Extracellular CLIC3 enhanced vascularization of matrigel plugs subcutaneously implanted and invasion in MCF10DCIS.com xenografts through the activation of TGM2.120 In α‐SMA+ and FAP+ CT5.3 patient‐derived colon cancer CAFs, FAP expression decreased levels of the anti‐angiogenic pigment epithelium‐derived factor (PEDF) while increased ANG1 and VEGFC to promote angiogenesis and lymphangiogenesis. Here, ACTA1 is linked to malignant colon neoplasm.