Depletion of α‐SMA+ proliferating cells either at non‐invasive pancreatic intraepithelial neoplasia or PDAC stage in KRasG12D model accelerated the progression of the disease.102 Similarly, deletion of the desmoplastic driver Sonic hedgehog (Shh) in the cancer cells of a PDAC model promoted aggressiveness.103 Patient‐derived mammary fibroblasts, 199Ct CAF line, and WI38 and HS68 fibroblast lines were found to secrete high levels of slit homolog 2 protein (SLIT2). Here, SLIT2 is linked to cancer.