Comparative proteomic analysis of murine CAFs isolated from sporadic colon cancer with their matched normal fibroblasts revealed upregulation of latent transforming growth factor beta binding protein 2 (LTBP2), farnesyl diphosphate synthase (FDPS), and cadherin 11 (CDH11) in CAFs. The gene discussed is LTBP2; the disease is malignant colon neoplasm.