Moreover, IHC analysis of NSCLC tissues showed that stromal IL‐6 levels correlate with EMT phenotype of cancer cells.98 CAFs isolated from human gastric carcinoma tissue secrete Galectin 1 (LGALS1), which binds to β1 integrin in MGC‐803 gastric cancer cells thus inducing EMT via upregulation of the glioma‐associated oncogene 1 (GLI1).99 Finally, CAFs can support invasion by establishing physical interactions with the cancer cells. The gene discussed is GLI1; the disease is cancer.