Targeting glutamine synthetase in the stroma and glutaminase in the cancer cells blocked this metabolic symbiosis and reduced tumor growth, burden, and metastasis in a SKOV3 orthotopic tumor model.136 EVs secreted by patient‐derived prostate CAFs and pancreatic CAF‐19 line supported growth of pancreatic and prostate cancer cell lines via KRas‐independent mechanisms. This evidence concerns the gene GLS and neoplasm.