CYP2D6 and Autoimmunity: The “non-self” alloreactive type of immune response has been ruled out for anti-LKM-1 antibody, whose serum positivity has been reported in genetically CYP-2D6 extensive metabolizer individuals affected by AIH-2 [5, 24], in whom a sufficiently high CYP-2D6 expression level is thought to be necessary to trigger autoimmunity [5].