While analyzing publicly available datasets for mutations in PIK3CB—namely, COSMIC (cancer.sanger.ac.uk,25) and The Cancer Genome Atlas (TCGA, viewed via cbioportal.org)—we noted a somatic mutation in the coding DNA sequence (CDS) at position 3151 (G to A substitution), resulting in an E1051K point mutation in p110β, that was present in 13 of the 251 samples containing mutations in PIK3CB (from a total 31780 samples tested). The gene discussed is PIK3CB; the disease is cancer.