It has been well characterized that circulating chemerin levels are higher in patients with obesity (Bozaoglu et al., 2007; Sell et al., 2009; Stefanov et al., 2014), and chemerin and CMKLR1 expression is upregulated in adipose tissue from obese subjects (Catalán et al., 2013). Here, CMKLR1 is linked to obesity due to melanocortin 4 receptor deficiency.