CMKLR2 and obesity due to melanocortin 4 receptor deficiency: Although no SNPs reported in the GPR1 or CMKLR1 gene implicate them with obesity and metabolic syndrome, there is a positive correlation found between common genetic variants in the RARRES2 gene (SNP rs17173608 and rs10278590) with increased visceral adiposity (Müssig et al., 2009).