ERBB2 and triple-negative breast carcinoma: More recently, Tingting et al. reported that the loss of PTPN12 activity by deletions, mutations, and loss of expression result in aberrant activation of the human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR)-centered receptor tyrosine kinase-signaling network, which involves more than 60 proteins, in triple negative breast cancer (TNBC) [16].