The pro-apoptotic function of Par-4 is affected by its binding via the leucine zipper domain to several proteins including Ak mouse strain thymoma/protein kinase C-zeta (Akt/PKC-ζ), nuclear factor kappa-light-chain-enhancer of activated B-cells/p65 subunit (NF-κB/p62), wilms tumor-1(WT1), DAPk like kinase/Zipper interacting protein kinase (DLk/ZIP), Thanatos-associated domain-containing apoptosis-associated protein 1 (THAP-1), and thus blocking pro-survival pathways [25,26,27,28]. The gene discussed is DAPK3; the disease is thymoma.