NFKB1 and cancer: Importantly, the same principle we developed of therapeutically inhibiting a cancer-restricted axis of the NF-κB pathway, rather than NF-κB globally, could be also applied to selectively targeting the NF-κB oncogenic function in GADD45β-independent malignancies and, plausibly, in the context of non-malignant NF-κB-driven diseases (Tornatore et al., 2014).