Notably, BCL-2-targeting drugs have been successfully developed outside the scope of blocking oncogenic NF-κB signalling, and drugs in this class, including the first-in-class BCL-2-family inhibitor, ABT-199 (venetoclax), have been granted breakthrough status designation by the FDA for treating subsets of patients with relapsed or refractory chronic lymphoid leukaemia (CLL) (Cang et al., 2015; Levy and Claxton, 2017). Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.