Moreover, there is a strong rationale for developing NF-κB-targeting therapeutics to treat numerous non-malignant human pathologies, such as diabetes, autoimmune disorders, and chronic inflammatory diseases, owing to the central role of NF-κB signalling in governing inflammation, and the underlying low-grade inflammatory reaction that propagates the pathogenesis of these and virtually all other human illnesses (Xia et al., 2014; DiDonato et al., 2012). Here, NFKB1 is linked to autoimmune disease.