Furthermore, Blumenfeld et al. [33] studied thousands of female patients in the United Kingdom and found that single nucleotide polymorphisms (SNPs) in the IL-6 genomic region were associated with radiographic evidence of hand OA and an “osteoporosis-related phenotype” of the hand, suggesting that specific DNA motifs in the IL-6 gene represented by these IL-6 SNPs contributed to the development of hand OA and osteoporotic-related changes in the hand. Here, IL6 is linked to osteoporosis.