Previous studies suggest IFN-γ as a good candidate for tumor-associated macrophage re-education due to the ability of IFN-γ to re-polarize tumor-associated macrophages toward an M1 phenotype in vitro (100) and its ability to render macrophages tumor-suppressive in mouse tumor models in vivo (31, 37–39). The gene discussed is IFNG; the disease is neoplasm.