Furthermore, DC paralysis in mouse models has been observed to be associated with upregulation of immune checkpoint receptors such as PD-1 and T cell immunoglobulin and mucin-domain containing-3 (TIM-3), which was reported to interact with the alarmin protein high mobility group box 1 (HMGB1) resulting in reduced DC sensing of tumor-derived nucleic acids (107). This evidence concerns the gene HMGB1 and neoplasm.