As the studies of the major genomic aberrations in melanoma have been extensively reviewed elsewhere, this section will describe a number of the most common driver mutations seen in cutaneous melanoma [BRAF, NRAS, NF1, microphthalmia-associated transcription factor (MITF), and PTEN] (4, 15, 25, 28, 31). This evidence concerns the gene MITF and cutaneous melanoma.