MTOR and melanoma: Due to the crucial role of NF1 upstream of RAS/MAPK and PI3K/mTOR pathways, NF1 mutant tumors have been targeted with tyrosine kinase inhibitors (e.g., imatinib), MEK inhibitors (trametinib), and mTOR inhibitors (sirolimus), but to date, none of these agents have been reported in treatment of NF1 mutant melanomas (40).