Furthermore, PD-L1 and/or PD-L2 are both observed to be expressed on a number of tumor-infiltrating APC and tumor cells themselves, not only as a result of cytokines but also due to alternative factors such as gain of chromosomes carrying PD-L1 and PD-L2 or the signaling of the epidermal growth factor pathway (167). The gene discussed is CD274; the disease is neoplasm.