CREB1 and memory impairment: It can also protect the memory deficits by inducing the expressions of BDNF and p-CREB in scopolamine-induced memory-deficient mice (Jung et al., 2012), anti-inflammatory amelioration of age-dependent memory impairment in Fischer 344 rats (Jeong et al., 2015), and ameliorate memory impairment and inflammation in D-galactose-induced accelerated aging mouse (Woo et al., 2014).