Analysis of non-chimeric mice with increasing AML infiltration by flow cytometry showed a progressive decrease of overall normal hematopoietic cells in the BM (Figure 1B) and more specifically of Lineage−, cKit+ Sca-1+ (LKS) progenitor cell and LKS CD48− CD150+ HSC populations (Figures 5A and S5A). This evidence concerns the gene CD48 and acute myeloid leukemia.