IVM of chimeras containing CFP+ osteoblastic cells, mTomato+ healthy hematopoietic cells, and YFP+GFP+ leukemia revealed that AML cells, as they remodel stroma and vessels locally, also outcompete healthy hematopoietic cells and eliminate osteoblastic cells (Figures 4C and 4D). The gene discussed is CFP; the disease is leukemia.