FN1 and idiopathic pulmonary fibrosis: Furthermore, western blotting confirmed the mEV-mediated decreases of α-SMA and FN-EDA expression at the protein level in normal fibroblasts (Fig. 1C) and the decreases of α-SMA and Col III in IPF fibroblasts treated with mEVs or mEVs-α-IgG (Fig. 1D).