Assessment of specific core enrichment genes in the NAFLD pathway (KEGG map04932) included upregulation of multiple Oxidative Phosphorylation genes associated with production of reactive oxygen species, as well as upregulation of adiponectin receptor (ADIPOR1; P = 0.02) and the interleukins IL1A (P = 0.008), IL1B (P = 0.005), and IL8 (P = 0.03) (data not shown). The gene discussed is IL1A; the disease is metabolic dysfunction-associated steatotic liver disease.