Direct inhibition of calcineurin with FK50630, 31, cyclosporine A (CsA)30, 31, or RNAi-mediated depletion of the calcineurin catalytic subunit (PPP3CB) was also sufficient to block TFEB activation by AD, suggesting small-molecule inhibition of PTPMT1 activates TFEB via mobilization of calcineurin catalytic activity (Fig. 4b–e and Supplementary Fig. 4b, c). Here, PPP3CB is linked to Alzheimer disease.