This cascade promotes cellular survival in non-neuronal tumor cells, through activation of I kappaB kinase (IKK) and nuclear factor-kappaB (NF-κB) that induces SOD2 transcription, a gene encoding the mitochondrial manganese-dependent superoxide dismutase (MnSOD) involved in ROS detoxification13–17. Here, NFKB1 is linked to neoplasm.