Findings demonstrated that subjects with higher number of FTO risk alleles and with the highest intake of fried foods and sugary beverages might be more susceptible to obesity than individuals with lower consumption of unhealthy food groups24, indicating that encouraging the consumption of low energy density and high fiber foods may be an effective public health strategy to avoid excessive fat accumulation and that FTO risk allele carriers could benefit more from dietary guidelines aimed at increasing dietary fiber intake. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.