CDKN2A and pancreatic neoplasm: In fact, it was shown that promoter methylation of E-cadherin1 (CDH1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) genes, encoding E-cadherin for an epithelial cell adhesion molecule and P16 for cell cycle regulator, respectively, correlated with the high occurrence of pancreatic cancer or rapid progression of the disease24,25.