It is of note that non-neoplastic tissues or subjects without PDC also showed methylation in 30% (10/33 subjects) in long-DM, 7% (4/59 subjects) in non-DM, 6% (1/17 subjects) in short-DM and 37% (7/19 subjects) in T2DM. The gene discussed is PDC; the disease is diabetes mellitus.