The drug target genes with comparable high CAP scores include tyrosinase (TYR; 62.4%, targeted by the acne drug azelaic acid), the alpha-4 subunit of the GABAA receptor GABRA4 (53%, targeted by benzodiazepines), and F5 (20.1%, targeted by drotrecogin alpha, which was withdrawn from the market due to unacceptable high numbers of adverse drug reactions) (Fig. 2). This evidence concerns the gene GABRA4 and acne.