The ADME genes with the highest CAP scores include NAT2 (81%, involved in metabolizing arylamine and hydrazine drugs), CYP2D6 (59.6%, involved in the metabolism of 20% of most prescribed drugs in the US [50]), and the transporter gene SLCO1B1 (26.0%, a high risk gene for simvastatin-related myopathy/rhabdomyolsis [51]). Here, CYP2D6 is linked to myopathy.