APP and Alzheimer disease: Other APPSwe transgenic lines have since been backcrossed to C57BL/6 for >10 generations without loss (i.e., APP/PS1 Line 85, C3–3, and J20), suggesting that this strain is not inherently problematic for AD models and that the premature lethality of Tg2576 likely arose from a specific interaction between the genomic integration site and genetic modifiers of the background strain.