Several common promoter constructs have been used over the years, including prion protein (Prnp, i.e., Tg2576 [95], TgCRND8 [51], APP/PS1 Line 85 [99], JNPL3 [34], and PS19 [33]), platelet-derived growth factor B chain (PDGFB, i.e., PDAPP [2] and J20 [54]), and thymus cell surface antigen 1 (Thy1, i.e., APP23 [100], 5XFAD [47], and 3xTg-AD [101]). Here, PSEN1 is linked to Alzheimer disease.